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With the proliferation Tablet Personal Computer (TPC) based mobile computing initiatives across campuses; evaluation of such initiatives becomes the logical next step. Yet for such initiatives to improve students’ learning and teaching effectiveness, such technology-based initiatives must be accepted by students and faculty alike. This research evaluates students’ acceptance of TPC as a means to forecast, explain, and improve usage pattern. The research utilizes the technology acceptance model as an underlying theoretical model and the Partial Least Square (PLS) to estimate the parameters of the causal model. Overall, the findings indicate that TAM is able to provide a reasonable of students’ acceptance of TPC with perceived usefulness a significant determinant of attitude and intention, perceived ease of use a significant determinant of usefulness and attitude.